ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro.
Identifieur interne : 000E75 ( Main/Exploration ); précédent : 000E74; suivant : 000E76ROS activates JNK-mediated autophagy to counteract apoptosis in mouse mesenchymal stem cells in vitro.
Auteurs : Guan-Yu Liu [République populaire de Chine] ; Xiao-Xue Jiang [République populaire de Chine] ; Xin Zhu [République populaire de Chine] ; Wei-Yang He [République populaire de Chine] ; You-Lin Kuang [République populaire de Chine] ; Ke Ren [République populaire de Chine] ; Yong Lin [États-Unis] ; Xin Gou [République populaire de Chine]Source :
- Acta pharmacologica Sinica [ 1745-7254 ] ; 2015.
Descripteurs français
- KwdFr :
- Activation enzymatique, Animaux, Apoptose, Autophagie, Dysfonctionnement érectile (), Espèces réactives de l'oxygène (métabolisme), Lignée cellulaire, MAP Kinase Kinase 4 (métabolisme), Mâle, Peroxyde d'hydrogène (métabolisme), Souris, Stress oxydatif, Survie cellulaire, Transplantation de cellules souches mésenchymateuses.
- MESH :
English descriptors
- KwdEn :
- Animals, Apoptosis, Autophagy, Cell Line, Cell Survival, Enzyme Activation, Erectile Dysfunction (therapy), Hydrogen Peroxide (metabolism), MAP Kinase Kinase 4 (metabolism), Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells (cytology), Mesenchymal Stem Cells (metabolism), Mice, Oxidative Stress, Reactive Oxygen Species (metabolism).
- MESH :
- chemical , metabolism : Hydrogen Peroxide, MAP Kinase Kinase 4, Reactive Oxygen Species.
- cytology : Mesenchymal Stem Cells.
- metabolism : Mesenchymal Stem Cells.
- therapy : Erectile Dysfunction.
- Animals, Apoptosis, Autophagy, Cell Line, Cell Survival, Enzyme Activation, Male, Mesenchymal Stem Cell Transplantation, Mice, Oxidative Stress.
Abstract
Transplantation of mesenchymal stem cells (MSCs) for the treatment of diabetic erectile dysfunction (ED) is hampered by apoptosis of the transplanted cells. In diabetic ED, there is increased oxidative stress and decreased NO in the corpora cavernosa, and reactive oxygen species (ROS) induce apoptosis of the transplanted cells. In this study we examined whether and how autophagy was involved in ROS-induced apoptosis of MSCs.
DOI: 10.1038/aps.2015.101
PubMed: 26592514
Affiliations:
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Le document en format XML
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wicri:level="1"><nlm:affiliation>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016</wicri:regionArea><wicri:noRegion>Chongqing 400016</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Xiao Xue" sort="Jiang, Xiao Xue" uniqKey="Jiang X" first="Xiao-Xue" last="Jiang">Xiao-Xue Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016</wicri:regionArea><wicri:noRegion>Chongqing 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Affiliated Hospital of Chongqing Medical University, Chongqing 400016</wicri:regionArea><wicri:noRegion>Chongqing 400016</wicri:noRegion></affiliation></author><author><name sortKey="Kuang, You Lin" sort="Kuang, You Lin" uniqKey="Kuang Y" first="You-Lin" last="Kuang">You-Lin Kuang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016</wicri:regionArea><wicri:noRegion>Chongqing 400016</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Ke" sort="Ren, Ke" uniqKey="Ren K" first="Ke" last="Ren">Ke Ren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016</wicri:regionArea><wicri:noRegion>Chongqing 400016</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yong" sort="Lin, Yong" uniqKey="Lin Y" first="Yong" last="Lin">Yong Lin</name><affiliation wicri:level="2"><nlm:affiliation>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Gou, Xin" sort="Gou, Xin" uniqKey="Gou X" first="Xin" last="Gou">Xin Gou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016</wicri:regionArea><wicri:noRegion>Chongqing 400016</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta pharmacologica Sinica</title><idno type="eISSN">1745-7254</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Autophagy</term><term>Cell Line</term><term>Cell Survival</term><term>Enzyme Activation</term><term>Erectile Dysfunction (therapy)</term><term>Hydrogen Peroxide (metabolism)</term><term>MAP Kinase Kinase 4 (metabolism)</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation</term><term>Mesenchymal Stem Cells (cytology)</term><term>Mesenchymal Stem Cells (metabolism)</term><term>Mice</term><term>Oxidative Stress</term><term>Reactive Oxygen Species (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation enzymatique</term><term>Animaux</term><term>Apoptose</term><term>Autophagie</term><term>Dysfonctionnement érectile ()</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Lignée cellulaire</term><term>MAP Kinase Kinase 4 (métabolisme)</term><term>Mâle</term><term>Peroxyde d'hydrogène (métabolisme)</term><term>Souris</term><term>Stress oxydatif</term><term>Survie cellulaire</term><term>Transplantation de cellules souches mésenchymateuses</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrogen Peroxide</term><term>MAP Kinase Kinase 4</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Mesenchymal Stem Cells</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mesenchymal Stem Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term><term>MAP Kinase Kinase 4</term><term>Peroxyde d'hydrogène</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Erectile Dysfunction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Autophagy</term><term>Cell Line</term><term>Cell Survival</term><term>Enzyme Activation</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation</term><term>Mice</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term><term>Animaux</term><term>Apoptose</term><term>Autophagie</term><term>Dysfonctionnement érectile</term><term>Lignée cellulaire</term><term>Mâle</term><term>Souris</term><term>Stress oxydatif</term><term>Survie cellulaire</term><term>Transplantation de cellules souches mésenchymateuses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transplantation of mesenchymal stem cells (MSCs) for the treatment of diabetic erectile dysfunction (ED) is hampered by apoptosis of the transplanted cells. In diabetic ED, there is increased oxidative stress and decreased NO in the corpora cavernosa, and reactive oxygen species (ROS) induce apoptosis of the transplanted cells. In this study we examined whether and how autophagy was involved in ROS-induced apoptosis of MSCs.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Nouveau-Mexique</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Guan Yu" sort="Liu, Guan Yu" uniqKey="Liu G" first="Guan-Yu" last="Liu">Guan-Yu Liu</name></noRegion><name sortKey="Gou, Xin" sort="Gou, Xin" uniqKey="Gou X" first="Xin" last="Gou">Xin Gou</name><name sortKey="He, Wei Yang" sort="He, Wei Yang" uniqKey="He W" first="Wei-Yang" last="He">Wei-Yang He</name><name sortKey="Jiang, Xiao Xue" sort="Jiang, Xiao Xue" uniqKey="Jiang X" first="Xiao-Xue" last="Jiang">Xiao-Xue Jiang</name><name sortKey="Kuang, You Lin" sort="Kuang, You Lin" uniqKey="Kuang Y" first="You-Lin" last="Kuang">You-Lin Kuang</name><name sortKey="Ren, Ke" sort="Ren, Ke" uniqKey="Ren K" first="Ke" last="Ren">Ke Ren</name><name sortKey="Zhu, Xin" sort="Zhu, Xin" uniqKey="Zhu X" first="Xin" last="Zhu">Xin Zhu</name></country><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Lin, Yong" sort="Lin, Yong" uniqKey="Lin Y" first="Yong" last="Lin">Yong Lin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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